Key result
Sigma-1 receptors emerge as a distinctive pharmacological target with novel therapeutic potential.
This paper reviews the emergence of the sigma-1 receptor as a pharmacological target and the potential of its agonists as therapeutic options.
Sigma-1 receptor modulation may offer novel CV targets; leaves open need for clinical validation.
Since its identification in the late 1970s as a putative subtype of opioid receptor, the sigma-1 (σ1) receptor has emerged as a highly distinctive pharmacological target. Initially reclassified ...
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Tangui Maurice (2026) studied this question. Sigma-1 receptors have emerged as a highly distinctive pharmacological target with potential as an emerging therapeutic option.
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