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June 29, 2026Hypertension

Changes in Retinal Microvasculature During Healthy Pregnancy Measured by AO

Anne Dathan‐Stumpf Emilie Martini Holger Stepan Radim Kolář Franziska G. Rauscher

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Key Points

This study aims to investigate changes in the wall-to-lumen ratio of retinal arterioles during healthy pregnancies.
Single-center, prospective study conducted at Leipzig University Hospital, Germany.
Examined 460 healthy singleton pregnancies with 543 measurements from first to third trimester.
Wall-to-lumen ratio calculated using adaptive optics and nnUNet deep learning model.
Increased wall-to-lumen ratio (WLR) linked to higher maternal age (p=0.012) and mean arterial pressure (p<0.001).
Multiparous women showed significantly lower WLR compared to nulliparous women with negligible multicollinearity.

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Implication

Examines retinal microvasculature changes in pregnancies, indicating adaptation during physiological conditions.

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Cite This Study

Dathan‐Stumpf et al. (2026) studied this question.

synapsesocial.com/papers/6a44afdc5cd2549c8bc44af6 https://doi.org/10.1161/hypertensionaha.125.26521

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Temporal Changes in Retinal Microvascular Caliber and Blood Pressure During Pregnancycohort · 2013 · 33 citations
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4Retinal Vascular Caliber: 6 to 12 Months and 15 to 25 Years Following Hypertensive PregnancyOriginal Research · 2026
5Retinal oximetry and microvascular assessment after hypertensive pregnancy complications2024 · 3 citations