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This review aims to summarize the molecular mechanisms underpinning iron overload and ferroptosis in hereditary hemochromatosis.

July 1, 2026Open Access

Iron Overload and Ferroptosis in Hereditary Hemochromatosis: Molecular Mechanisms and Therapeutic Perspectives

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This review aims to summarize the molecular mechanisms underpinning iron overload and ferroptosis in hereditary hemochromatosis.
Analysis of molecular pathways related to iron metabolism and ferroptosis
Discussion of recent therapeutic strategies targeting iron overload
Review of existing evidence linking ferroptosis to clinical manifestations of hereditary hemochromatosis.
Identified oxidative stress and mitochondrial injury as outcomes of iron overload.
Highlighted ferroptosis as a key mechanism of tissue damage in hereditary hemochromatosis.
Proposed therapeutic interventions such as iron chelation and antioxidant strategies for clinical application.

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Review reveals mechanisms linking iron overload to tissue injury in hereditary hemochromatosis, suggesting new treatment options.

Tahira Asgarova*1, Huseyn Abiyev2, Nigar Malikova1, Elshad Novruzov1 (2026) studied this question.

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