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This review examines the biogenesis and roles of outer membrane vesicles (OMVs) in Gram-negative bacteria, particularly in relation to bacterial pathogenicity and host interaction.

July 1, 2026Communications BiologyOpen Access

New insights into outer membrane vesicles in Gram-negative bacteria from biogenesis to applications

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This review examines the biogenesis and roles of outer membrane vesicles (OMVs) in Gram-negative bacteria, particularly in relation to bacterial pathogenicity and host interaction.
Summarizes mechanisms of OMV biogenesis and cargo remodeling under environmental stress.
Explores host cell interactions facilitated by OMVs and their potential immunomodulatory effects.
Reviews applications of OMVs in vaccine development and therapeutic strategies.
Identifies envelope instability as a key driver of OMV biogenesis influenced by stress conditions.
Highlights the functional roles of OMVs in immune evasion and microbiota homeostasis.
Discusses their potential use as innovative vaccine platforms for therapeutic and prophylactic applications.

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Review highlights mechanisms of outer membrane vesicle biogenesis and their therapeutic applications in bacterial physiology.

Cite This Study

Kim et al. (2026) studied this question.

synapsesocial.com/papers/6a44afdc5cd2549c8bc44beb https://doi.org/10.1038/s42003-026-10562-9

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New insights into outer membrane vesicles in Gram-negative bacteria from biogenesis to applications

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Discussion

Implication

Cite This Study

New insights into outer membrane vesicles in Gram-negative bacteria from biogenesis to applications

Key Points

Discussion

Implication

Cite This Study

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