Randomized trial examines enhanced solubility and permeability of ibuprofen in a novel hydrogel formulation, suggesting improved drug delivery methods.
Key Points
The aim was to determine if N-methyl-D-glucosamine could enhance the solubility and pharmaceutical properties of ibuprofen hydrogel.
IBU-GLU hydrogel was prepared by mixing ibuprofen with N-methyl-D-glucosamine in deionized water.
Characterization involved SEM, rheology, DSC, PXRD, and FTIR analyses.
In vitro solubility, release, and permeability tests were conducted.
The IBU-GLU hydrogel improved ibuprofen solubility by 38.4-fold compared to pure ibuprofen.
Superior release rates and enhanced supersaturation abilities were observed.
Accelerated membrane permeation of ibuprofen was noted compared to commercially available ibuprofen hydrogel.