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February 2, 2026Pakistan Journal of Pharmaceutical SciencesOpen Access

Design And Optimization Of Ibuprofen Microemulgel Using Phase Titration For Effective And Enhanced Dermal Drug Delivery

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Authors

AJAmna Nosheen JaweriaSKSehar KhalidMMMaiza Mubashaar

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Overview

Develops a microemulgel to improve ibuprofen delivery in the skin, suggesting a new formulation approach.

Key Points

  • The aim is to create and optimize an ibuprofen microemulgel to enhance solubility and permeability for better skin application.
  • Prepared microemulsions via phase titration using Tween 80, butanol, and vegetable oil.
  • Incorporated carbopol gel for microemulgel formation.
  • Conducted preformulation studies on solubility and partition coefficients.
  • Characterized the formulation through globule size, zeta potential, pH, and drug content analyses.
  • Evaluated compatibility using FTIR and DSC techniques.
  • The optimized formulation (F3) had a droplet size of 117.5 nm and a zeta potential of -6.47 mV.
  • The drug content was measured at 82.94%.
  • Ex-vivo studies showed enhanced skin permeability.
  • Drug release followed the Korsmeyer–Pappas model indicating non-Fickian diffusion.

Cite This Study

Jaweria et al. (2026) studied this question.

synapsesocial.com/papers/69810006c1c9540dea813117https://doi.org/10.36721/pjps.2026.39.3.reg.14627.1
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