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May 4, 2026Open Access

Systematic Screening of Oil, Surfactant, and Cosurfactant for Ibuprofen Nanoemulsion

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Authors

RWRina WidiastutiANAkhmad Kharis NugrohoRMRonny Martien

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Overview

Randomized trial screens optimal components for ibuprofen nanoemulsion delivery, suggesting improved therapy options.

Key Points

  • This study aims to identify optimal oil, surfactant, and cosurfactant for ibuprofen nanoemulsions to enhance topical delivery.
  • Screened various oils for ibuprofen solubility, identifying Capryol 90 as optimal.
  • Evaluated surfactants and cosurfactants based on emulsification efficiency and physical stability.
  • Prepared nanoemulsions using high-energy sonication and characterized droplet size and drug loading.
  • Capryol 90 demonstrated the highest ibuprofen solubility at 103.01 ± 0.53 mg/mL.
  • Kolliphor RH 40 produced nanoemulsions with average droplet size of 109.7 ± 56.9 nm and PDI of 0.214 ± 0.02.
  • Transcutol P achieved the highest drug loading capacity of 280 mg/mL, contributing to formulation stability.

Cite This Study

Widiastuti et al. (2025) studied this question.

synapsesocial.com/papers/69f837c23ed186a739981f9fhttps://doi.org/10.18596/jotcsa.1787016
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