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June 5, 2026Open Access

Formulation and Evaluation of Microemulsion Based Topical Drug Delivery System for Ibuprofen

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Authors

DGDr. Bipin Gandhi*AMApoorva MulimaniASAlfiya Shaikh

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Overview

Randomized trial evaluates drug permeation of ibuprofen in a microemulsion, suggesting improved formulation benefits.

Key Points

  • This work aims to formulate and evaluate a ibuprofen-loaded topical microemulsion to enhance localized drug action and reduce systemic side effects.
  • Developed an ibuprofen microemulsion using Isopropyl Myristate, Span 80, and ethanol in a 6:4 ratio.
  • Assessed physicochemical properties including pH, viscosity, and drug content.
  • Conducted in vitro drug permeation studies using a Franz diffusion cell.
  • The optimized microemulsion exhibited a pH of 6.0 ± 0.1 and viscosity of 99.9 mPa·s.
  • Demonstrated sustained drug release for up to 12 hours in PBS (pH 7.4).
  • Achieved 102.8% drug incorporation with good physical stability and no phase separation.

Cite This Study

Gandhi* et al. (2026) studied this question.

synapsesocial.com/papers/6a22692e763171746d547ca7https://doi.org/10.5281/zenodo.20527739
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Also Consider

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  1. 1Design And Optimization Of Ibuprofen Microemulgel Using Phase Titration For Effective And Enhanced Dermal Drug Delivery2026
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  4. 4DEVELOPMENT AND EVALUATION OF A EUTECTIC-BASED SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR SOLUBILITY AND PERMEATION2026
  5. 5Integrating Molecular Modeling and Nanoemulsion Characterization for Ibuprofen2026