What does this research mean for the field?

Nanoemulsion formulations of ibuprofen exhibit superior physicochemical properties compared to traditional emulsion formulations, demonstrating enhanced stability and potential for improved drug delivery. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

The research aims to explore the properties of ibuprofen's polymorphic forms and their impact on emulsion systems.

February 28, 2026ACS OmegaOpen Access

Integrating Molecular Modeling and Nanoemulsion Characterization for Ibuprofen

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Authors

AAAntônio S. N. Aguiar LALuana A. F. Afiune VSVitória A. M. Silva

Discussion

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Overview

This investigation reveals nanoemulsion's superiority in drug delivery efficiency for ibuprofen, highlighting improved stability.

Key Points

The research aims to explore the properties of ibuprofen's polymorphic forms and their impact on emulsion systems.
Conducted structural and electronic analysis of ibuprofen polymorphs using density functional theory.
Prepared two formulations: an emulsion (EM-IBU) and a nanoemulsion (NE-IBU).
Characterized formulations through droplet size, polydispersity index, zeta potential, density, and drug content measurements.
NE-IBU showed a significantly smaller particle size of 31.3 nm compared to 235.4 nm for EM-IBU.
NE-IBU had a lower polydispersity index (0.16) compared to EM-IBU (0.23).
NE-IBU exhibited a more negative zeta potential of -25.8 mV, indicating better stability than EM-IBU's -22.1 mV.
Higher density for NE-IBU (0.989 g/cm³) compared to EM-IBU (0.967 g/cm³) suggests enhanced formulation efficiency.

Cite This Study

Aguiar et al. (2026) studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00e25 https://doi.org/10.1021/acsomega.5c09579

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February 28, 2026ACS OmegaOpen Access

Integrating Molecular Modeling and Nanoemulsion Characterization for Ibuprofen

View Full Paper

Ask AI

Bookmark

Authors

AAAntônio S. N. Aguiar LALuana A. F. Afiune VSVitória A. M. Silva

Discussion

Member takes

Overview

This investigation reveals nanoemulsion's superiority in drug delivery efficiency for ibuprofen, highlighting improved stability.

Key Points

The research aims to explore the properties of ibuprofen's polymorphic forms and their impact on emulsion systems.
Conducted structural and electronic analysis of ibuprofen polymorphs using density functional theory.
Prepared two formulations: an emulsion (EM-IBU) and a nanoemulsion (NE-IBU).
Characterized formulations through droplet size, polydispersity index, zeta potential, density, and drug content measurements.
NE-IBU showed a significantly smaller particle size of 31.3 nm compared to 235.4 nm for EM-IBU.
NE-IBU had a lower polydispersity index (0.16) compared to EM-IBU (0.23).
NE-IBU exhibited a more negative zeta potential of -25.8 mV, indicating better stability than EM-IBU's -22.1 mV.
Higher density for NE-IBU (0.989 g/cm³) compared to EM-IBU (0.967 g/cm³) suggests enhanced formulation efficiency.

Cite This Study

Aguiar et al. (2026) studied this question.

synapsesocial.com/papers/69a286240a974eb0d3c00e25 https://doi.org/10.1021/acsomega.5c09579

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