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June 6, 2026Open Access

Development and Evaluation of a Eutectic-Based Self-Microemulsifying Drug Delivery System for Solubility and Permeation

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Authors

2A2Miss. Shraddha Madan Khaladkar *1Marne Gandharva Anil

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Overview

Randomized trial demonstrates improved solubility and permeation of ibuprofen using a new eutectic delivery system, suggesting better medication options.

Key Points

  • The research aims to enhance the solubility and permeation of ibuprofen using a novel self-microemulsifying drug delivery system.
  • Utilized a therapeutic deep eutectic solvent with ibuprofen and L-menthol as the base ingredients.
  • Formulated a solid self-microemulsifying drug delivery system (F5) using polysorbate 80 and polyethylene glycol 400.
  • Conducted tests on the new formulation's solubility and permeation using pig tissue samples.
  • F5 contained 42.5% ibuprofen, providing a high concentration for enhanced delivery.
  • Medicine mixed with water in about 48 seconds, indicating rapid solubility.
  • The permeation through pig tissue improved 5.8 times compared to traditional delivery methods.

Cite This Study

2Miss. Shraddha Madan Khaladkar *1Marne Gandharva Anil (2026) studied this question.

synapsesocial.com/papers/6a23bbeb71a5da9775e77554https://doi.org/10.5281/zenodo.20537319
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