Abstract Background Hybrid-SVF, a combination of mechanical stromal vascular fraction (M-SVF) and stromal vascular matrix fraction (M-SVM), is an alternative method to overcome limitations of low cell counts by conventional mechanical and enzymatic methods. Objectives Observation of volume retention in facial fat grafts enhanced with Hybrid M-SVF and platelets in pure platelet-rich plasma (P-PRP). Methods Using a 5:1 v/v ratio, proportional volumes of micro-fat to proportional volumes and quantitative cell counts of M-SVF/MSVM and PRP were delivered to palpebral-malar groove/malar fat pad units and evaluated by Vectra® Analysis for volumetric changes over 12 months. Results Collective analysis of 9 female patients (average age: 65.6 y) revealed the percentage volume retention increased from baseline to 3 months (54.9%), then progressively declined to its nadir at 5-7 months (38.4%), then rebounded to peak percentage values at 10-12 months (69.5%), p ˃ 0.05. Investigators’ ratings on the IGAIS scale are assessed. There were no reported long-term side effects or complications. Conclusions The application of M-SVF/M-SVM and platelets supported micro-fat grafting with simultaneous face (neck) lifting in a safe manner for patients older than 55 years of age in this preliminary study. However, the hypothesis-generated associations of SVF/SVM and platelets to improve volumetric fat changes were observational only, so that conclusions of a causal relationship could not be established in this limited uncontrolled trial. Thus, interpretation of results should be viewed with caution until future randomized controlled trials (RCT) are completed.
Gordon Sasaki (Mon,) studied this question.
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