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This research aims to develop a flow electrochemical method for selective reductive defluorocarboxylation of difluoromethylarenes.

Continuous‐Flow Electrochemical Selective Carboxylation of Difluoromethylarenes With CO ₂

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This research aims to develop a flow electrochemical method for selective reductive defluorocarboxylation of difluoromethylarenes.
Utilized a continuous-flow electrochemical system for the reaction.
Conducted cyclic voltammetry to study reaction mechanisms.
Evaluated substrate scope for scalability.
Demonstrated excellent chemoselectivity in the reaction.
Flow technology effectively suppressed over-reduction of products.
Successfully applied the method to a broad range of difluoromethylarenes.

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Randomized trial explores selective carboxylation in difluoromethylarenes, indicating a novel industrial application.

Peng et al. (2026) studied this question.

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