Key result
Coronary perivascular adipose tissue inflammation on PET and CT drives coronary artery spasm.
Non-invasive imaging modalities like 18F-FDG PET and cardiac CT offer mechanistic insights and represent potentially useful clinical tools for examining the presence and severity of vasospastic angina.
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May aid non-invasive assessment of vasospastic angina; leaves open whether targeting perivascular inflammation improves outcomes.
Perivascular adipose tissue, which constitutes perivascular components along with the adventitial vasa vasorum, plays an important role as a source of various inflammatory mediators in cardiovascular disease. Inflammatory changes in the coronary adventitia are thought to be involved in the pathogenesis of coronary artery spasm and vasospastic angina. Recent advances in translational research using non- invasive imaging modalities, including 18F-fluorodeoxyglucose PET and cardiac CT, have enabled us to visualise perivascular inflammation in the pathogenesis of coronary artery spasm. These modality approaches appear to be clinically useful as a non-invasive tool for examining the presence and severity of vasospastic angina.
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Ohyama et al. (2019) conducted a review in Coronary artery spasm and vasospastic angina. Perivascular adipose tissue inflammation was evaluated. Recent translational imaging research indicates that coronary perivascular adipose tissue inflammation, visualized by 18F-FDG PET and cardiac CT, plays a key role in the pathogenesis of coronary artery spasm.
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