Why the study?
Coronary artery inflammation drives CAD events and alters local cardiac adipose depots, prompting the need to summarize CT-based imaging of EAT and PCAT attenuation as surrogate markers of coronary inflammation.
Does PCAT attenuation on coronary CTA serve as a surrogate marker for coronary inflammation and risk of major coronary events?
Does PCAT attenuation on coronary CTA serve as a surrogate marker for coronary inflammation and risk of major coronary events?
PCAT attenuation on coronary CTA is emerging as a promising non-invasive imaging tool to quantify coronary inflammation and predict major coronary events.
Supports PCAT attenuation as a potential surrogate for coronary inflammation; observational data leave open its use in clinical risk prediction.
A large body of evidence arising from recent randomized clinical trials demonstrate the association of vascular inflammatory mediators with coronary artery disease (CAD). Vascular inflammation localized in the coronary arteries leads to an increased risk of CAD-related events, and produces unique biological alterations to local cardiac adipose tissue depots. Coronary computed tomography angiography (CTA) provides a means of mapping inflammatory changes to both epicardial adipose tissue (EAT) and pericoronary adipose tissue (PCAT) as independent markers of coronary risk. Radiodensity or attenuation of PCAT on coronary CTA, notably, provides indirect quantification of coronary inflammation and is emerging as a promising non-invasive imaging implement. An increasing number of observational studies have shown robust associations between PCAT attenuation and major coronary events, including acute coronary syndrome, and 'vulnerable' atherosclerotic plaque phenotypes that are associated with an increased risk of the said events. This review outlines the biological characteristics of both EAT and PCAT and provides an overview of the current literature on PCAT attenuation as a surrogate marker of coronary inflammation.
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Yuvaraj et al. (2021) studied this question.
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