Why the study?
The study assessed whether pericoronary adipose tissue CT attenuation, as an imaging biomarker of coronary inflammation, could distinguish different stages of coronary artery disease.
Does pericoronary adipose tissue (PCAT) CT attenuation distinguish between different stages of coronary artery disease (acute MI, stable CAD, and no CAD)?
Population
60 patients with acute MI matched to 60 with stable CAD and 60 controls with no CAD
Comparison
Acute MI vs stable CAD vs no CAD controls
Design
Cross-sectional study
Key result
Pericoronary adipose tissue CT attenuation independently distinguished stages of coronary artery disease, being highest in acute MI (-82.3 HU) versus stable CAD (-90.6 HU) and controls (-95.8 HU).
Authors
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May support noninvasive CAD staging; leaves open prognostic value and need for prospective validation.
Cross-Sectional (n=180)
Does pericoronary adipose tissue (PCAT) CT attenuation distinguish between different stages of coronary artery disease (acute MI, stable CAD, and no CAD)?
Absolute Event Rate: -82.3% vs -95.8%
p-value: p=<0.001
PCAT CT attenuation serves as a quantitative imaging biomarker of coronary inflammation that can independently distinguish between acute MI, stable CAD, and no CAD.
Lin et al. (2020) conducted a cross-sectional in Coronary artery disease (n=180). Pericoronary adipose tissue (PCAT) CT attenuation vs. Stable CAD and no CAD controls was evaluated on PCAT CT attenuation around the proximal RCA (p=<0.001). Pericoronary adipose tissue CT attenuation independently distinguished stages of coronary artery disease, being highest in acute MI (-82.3 HU) versus stable CAD (-90.6 HU) and controls (-95.8 HU).
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