Key result
HFpEF is a complex disorder driven by endothelial dysfunction and comorbidities, for which exercise training is currently the only available therapy to improve aerobic capacity and quality of life.
Why the study?
Heart failure with preserved ejection fraction represents a major unmet clinical need arising from complex cardiac and noncardiac pathophysiological abnormalities influenced by comorbidities.
This review highlights the complex pathophysiology of HFpEF involving cardiac and noncardiac factors, comorbidities, and microRNAs, while emphasizing exercise training as a key therapeutic intervention.
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May inform HFpEF management strategies; leaves open which targeted therapies improve outcomes in prospective trials.
Gevaert et al. (2019) conducted a review in Heart failure with preserved ejection fraction (HFpEF). HFpEF is a complex disorder driven by endothelial dysfunction and comorbidities, for which exercise training is currently the only available therapy to improve aerobic capacity and quality of life.
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