Key result
Chronic estrogen supplementation in ovariectomized rats significantly attenuated the emotional stress-induced increase in systolic blood pressure (147.8 vs 164.3 mmHg) and heart rate, while reducing cellular activation in the central nervous system and heart.
Why the study?
Does estrogen supplementation improve emotional stress-induced cardiovascular responses in ovariectomized rats?
Does estrogen supplementation improve emotional stress-induced cardiovascular responses in ovariectomized rats?
Mean Difference: -16.5
Absolute Event Rate: 147.8% vs 164.3%
p-value: p=<0.05
Estrogen supplementation in ovariectomized rats attenuates stress-induced cardiovascular responses via central nervous system modulation and direct cardiac effects, providing mechanistic insight into Takotsubo cardiomyopathy.
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Estrogen attenuates stress-induced cardiovascular responses in rats; leaves open translation to postmenopausal women.
Ueyama et al. (2007) studied Emotional stress-induced cardiovascular responses (Takotsubo cardiomyopathy model) (n=49). Estrogen supplementation (17β-estradiol) vs. Ovariectomy without estrogen supplementation (OVX) was evaluated on Systolic blood pressure at the end of immobilization stress (MD -16.5 mmHg, p=<0.05). Chronic estrogen supplementation in ovariectomized rats significantly attenuated the emotional stress-induced increase in systolic blood pressure (147.8 vs 164.3 mmHg) and heart rate, while reducing cellular activation in the central nervous system and heart.
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