Key result
In critically ill patients admitted for non-cardiac reasons, an increase in IL-6 by one standard deviation was independently associated with a 16% to 23% rise in cardiac troponin T.
Population
172 adult patients admitted to the intensive care unit for non-cardiac reasons in two tertiary care centers…
Design
Cohort, Laboratory biochemists and cardiologists adjudicating ECGs were…
Follow-up
up to 14 days
Authors
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cTnT elevation is common in noncardiac ICU admissions but definite MI infrequent; leaves open its link to inflammation and need for cardiac evaluation.
Cohort (n=172)
Yes
Effect estimate: 16% to 23% rise in cTnT
p-value: p=<0.05
In critically ill patients admitted for non-cardiac reasons, elevated cardiac troponin T is independently associated with markers of systemic inflammation (IL-6) and ventricular dilatation (NT-proBNP).
Ostermann et al. (2016) conducted a cohort in Critical illness (non-cardiac ICU admission) (n=172). Systemic inflammation (IL-6) and ventricular dilatation (NT-proBNP) vs. Lower or baseline biomarker levels was evaluated on Percentage change in cardiac troponin T (cTnT) associated with a one standard deviation increase in IL-6 (16% to 23% rise in cTnT, p=<0.05). In critically ill patients admitted for non-cardiac reasons, an increase in IL-6 by one standard deviation was independently associated with a 16% to 23% rise in cardiac troponin T.