Prevalence and predictors of silent atherosclerosis across life: Design of the REACT Phase 1 study
Key result
REACT Phase 1 cohort will use multi-territory imaging to map silent atherosclerosis prevalence and predictors.
- n=16,000
Why the study?
Current ASCVD preventive strategies exclude young adults under 40 and fail to account for the presence of actual silent atherosclerosis, limiting precision at the individual level.
What is the prevalence and what are the predictors of silent atherosclerosis in adults aged 18-70 without prior ASCVD?
Population
16,000 representative adults aged 18-70 years from Denmark and Spain without a history of ASCVD
Comparison
Prevalence and predictors of silent atherosclerosis across age and sex strata
Design
Prospective cohort study
Authors
Discussion
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Implication
May guide personalized ASCVD prevention; leaves open whether routine imaging alters outcomes in asymptomatic adults.
Study Design
Type
Cohort (n=16,000)
Multicenter
Yes
Structured PICO
What is the prevalence and what are the predictors of silent atherosclerosis in adults aged 18-70 without prior ASCVD?
P
Population
16,000 representative adults aged 18-70 years without a history of ASCVD from Denmark and Spain, enrolled to determine the prevalence and predictors of silent atherosclerosis.
E
Exposure
Assessment of silent atherosclerosis via 3D vascular ultrasound (carotid, femoral), computed tomography angiography (coronary, carotid, femoral), retina imaging, and multi-omics profiling.
O
Outcome
Prevalence of silent atherosclerosis across the lifespan and identification of sex- and age-specific predictors.surrogate
The REACT Phase 1 study is a large prospective cohort designed to map the prevalence and predictors of silent atherosclerosis across the lifespan using advanced multi-territory imaging and multi-omics to inform personalized ASCVD prevention.
Cite This Study
Hasselbalch et al. (2026) conducted a cohort in Silent atherosclerosis (n=16,000). Traditional and advanced risk factors was evaluated on Prevalence of silent atherosclerosis and its sex- and age-specific predictors. The REACT Phase 1 study is a prospective cohort designed to enroll 16,000 adults aged 18-70 to determine the prevalence and predictors of silent atherosclerosis using multi-territory imaging.