Key result
Fasting glucose above 5.2 mmol/L is linked to ~44% higher CHD odds in nondiabetic women.
Why the study?
Although CHD incidence increases with rising fasting plasma glucose in individuals without diabetes, the threshold of FPG for CHD in rural areas of China remains unclear.
Does elevated fasting plasma glucose increase the risk and severity of coronary heart disease in a nondiabetic rural Chinese population?
Observational (n=2,987)
No
Does elevated fasting plasma glucose increase the risk and severity of coronary heart disease in a nondiabetic rural Chinese population?
Answers are grounded in this paper and cite their sources.
Fasting plasma glucose > 5.2 mmol/L is an independent risk factor for the presence and severity of angiographic coronary heart disease in nondiabetic women, but not men, in rural China.
Even in individuals without diabetes, the incidence of coronary heart disease (CHD) increases with the rise in fasting plasma glucose (FPG); however, the threshold of FPG for CHD in rural areas of China is unclear. We retrospectively examined 2,987 people. Coronary angiography records were used to determine the presence of CHD as well as its severity. Risk factors for CHD and the relationship between different levels of FPG and CHD were analyzed. After adjusting for age, hypertension, dyslipidemia, smoking, drinking, chronic kidney disease, and previous ischemic stroke, the incidence of CHD in nondiabetic women began to increase when FPG exceeded 5.2 mmol/L (odds ratio (OR) = 1.438, 95% confidence interval (CI) = 1.099–1.880, p = 0.008), and the degree of coronary artery lesions also became more severe (OR = 1.406, 95% CI = 1.107–1.788, p = 0.005). However, no such correlations were found in nondiabetic men. In conclusion, among the nondiabetic women in rural areas of northern Henan, both the incidence of CHD and the severity of lesions increased when FPG levels were greater than 5.2 mmol/L, while no significant correlation between FPG and CHD was observed in diabetes‐free men.
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Guo et al. (2020) conducted an observational in Coronary heart disease (n=2,987). Fasting plasma glucose > 5.2 mmol/L vs. Fasting plasma glucose ≤ 5.2 mmol/L was evaluated on Incidence of coronary heart disease in nondiabetic women (OR 1.438, 95% CI 1.099-1.880, p=0.008). Fasting plasma glucose levels greater than 5.2 mmol/L were associated with a significantly increased incidence of coronary heart disease in nondiabetic women (OR 1.438), but not in men.
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