Sex Different Relation of Plasma Lipids to Fasting Plasma Glucose in Non-Diabetic Urban Chinese, a Cross-Section Study: Pp.17.152

Background: The association between dyslipidemia and elevated fasting glucose in type 2 diabetes is well known. In non-diabetes, whether this association still exists, and whether dyslipidemia is an independent risk factor for high FPG levels are not clear. Methods: This cross-sectional study recruited 3,460 non-diabetic Chinese subjects (1,027 men, and 2,433 women, aged 35–75 years) who participated in a health survey. Men and women were classified into tertiles by levels of plasma lipids respectively. Results: In women, the prevalence of impaired fasting glucose (IFG) was decreased with increased HDL-C. A stepwise increase in HDL-C was associated with decreasing FPG levels (lowest tertiles, FPG: 5.376±0.018; middle tertiles, 5.324±0.018; highest tertiles, 5.276±0.018 mmol/L; p = 0.001). Reversely, FPG levels increased from lowest tertiles to highest tertiles of LDL-C, TC, and TG. After multivariable adjustment HDL-C (¦Â = -0.074, p = 0.006), LDL-C (¦Â = 0.119, p = 0.029), and TG (¦Â = 0.070, p = 0.011) were predictors of FPG independent from age, BMI, and waist/hip ratio. we found that women in the first tertile with lower HDL-C level had a 1.75-fold increase in risk of IFG compared with non-diabetic women in the third tertile with higher HDL-C level (OR: 1.75, 95% CI: 1.20–2.56). In men, no significant association was found. We took age, BMI, waist/hip ratio, education, smoking, alcohol drinking, and physical exercise as adjusted variables. Conclusion: In Chinese non-diabetic women, dyslipidemia is associated with high levels of FPG; TG, HDL-C, and LDL-C are predictors of IFG independent of BMI and waist/hip ratio; low HDL-C and high TG are risk of IFG.