Key result
Enhancing cGMP signaling may improve glucose metabolism and affect the cardiovascular system, though excessive production could have unwanted cardiovascular and metabolic effects.
Why the study?
Cardiovascular and metabolic diseases are closely linked, motivating a review of the cGMP system and its crosstalk between metabolism and the cardiovascular system.
Does enhancing cGMP signaling improve glucose metabolism and cardiovascular outcomes in cardiometabolic disease?
Does enhancing cGMP signaling improve glucose metabolism and cardiovascular outcomes in cardiometabolic disease?
Enhancing cGMP signaling represents a potential therapeutic target for improving glucose metabolism in cardiometabolic disease, though safety requires further study.
May support cGMP-targeted therapies in cardiometabolic disease; leaves open need for RCTs on efficacy, dosing, and safety.
PURPOSE OF REVIEW: Cardiovascular and metabolic diseases are closely linked and commonly occur in the same patients. This review focuses on the cyclic guanosine monophosphate (cGMP) system and its crosstalk between metabolism and the cardiovascular system. RECENT FINDINGS: Recent studies suggest that cGMP, which serves as second messenger for nitric oxide and for natriuretic peptides, improves oxidative metabolism and insulin signaling. The clinical evidence is particularly strong for the natriuretic peptide branch of the cGMP system. Clinical trials suggested improvements in insulin sensitivity and reductions in the risk of progressing to type 2 diabetes mellitus. However, further studies are needed. SUMMARY: Enhancing cGMP signaling through nonpharmacological or pharmacological means may improve glucose metabolism in addition to affecting the cardiovascular system. However, excessive cGMP production could have significant unwanted cardiovascular and metabolic effects.
No takes yet. Share an insight, caveat, or question.
Jordan et al. (2019) conducted a review in Cardiometabolic disease. cGMP manipulation was evaluated. Enhancing cGMP signaling may improve glucose metabolism and affect the cardiovascular system, though excessive production could have unwanted cardiovascular and metabolic effects.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: