Why the study?
Does increased NO production and cGMP decrease myocardial glucose utilization and limit heart work in isolated rat hearts?
Population
Isolated working rat hearts perfused with glucose as the substrate
Comparison
8-bromoguanosine 3',5'-cyclic monophosphate… vs Control conditions without the addition of cGMP…
Design
Preclinical
Authors
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NO-cGMP signaling may limit myocardial glucose use and work in isolated rat hearts; leaves open translation to in vivo or human cardiac metabolism.
Does increased NO production and cGMP decrease myocardial glucose utilization and limit heart work in isolated rat hearts?
Increased nitric oxide production decreases myocardial glucose utilization and limits heart work via cGMP, highlighting its metabolic regulatory properties.
Depré et al. (1998) studied this question.
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