September 1, 1996Cardiovascular ResearchOpen Access

Inhibition of - but not a 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP

View Full Paper

Ask AI

Bookmark

Population

Electrically-paced isolated perfused rat hearts and ventricular myocytes

Comparison

Nitric oxide donors, NO synthase inhibitor, or… vs Isoproterenol or phenylephrine alone

Design

Preclinical

Authors

YEYoshinori EbiharaTokyo Gakugei University MKMorris KarmazynHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Supports NO/cGMP attenuation of beta-adrenergic responses in rat models; leaves open translation to human physiology or therapy.

Structured PICO

Population

Electrically-paced isolated perfused rat hearts and ventricular myocytes

Intervention

Nitric oxide (NO) donors (SNAP 10 microM, SIN-1 10 microM), NO synthase inhibitor (L-NAME 10 microM), or 8-bromo-cGMP (50 microM) in the presence of isoproterenol or phenylephrine

Comparator

Isoproterenol or phenylephrine alone

Outcome

Myocardial contractility (left ventricular developed pressure in isolated hearts; cell shortening and intracellular calcium transients in myocytes)surrogate

Nitric oxide and cGMP analogues attenuate beta-adrenergic, but not alpha-1-adrenergic, cardiac responses in isolated rat hearts and cardiomyocytes.

Cite This Study

Ebihara et al. (1996) studied this question.

synapsesocial.com/papers/6a868bbf4b115576a3d0a554 https://doi.org/10.1016/s0008-6363(96)00117-4

View Full Paper

Ask AI

Bookmark

Inhibition of - but not a 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inhibition of - but not a 1-mediated adrenergic responses in isolated hearts and cardiomyocytes by nitric oxide and 8-bromo cyclic GMP

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider