Key result
Dietary weight loss significantly decreased plasma ADMA concentrations in insulin-resistant obese women from 1.69 to 1.20 micromol/liter (P<0.001), but had no effect in insulin-sensitive obese women.
Why the study?
Does dietary weight loss reduce plasma ADMA concentrations in obese insulin-resistant women?
Does dietary weight loss reduce plasma ADMA concentrations in obese insulin-resistant women?
Absolute Event Rate: 1.2% vs 1.69%
p-value: p=<0.001
Dietary weight loss significantly reduces elevated plasma ADMA levels in obese insulin-resistant women, correlating with improvements in insulin sensitivity.
Hypothesis-generating for ADMA as a weight loss-responsive marker in insulin resistance; leaves open effects on cardiovascular outcomes.
CONTEXT: Plasma asymmetric dimethylarginine (ADMA) concentrations are higher in apparently healthy, insulin-resistant (IR) individuals and decrease in response to thiazolidenedione treatment. OBJECTIVE: The objective of the study was to determine whether ADMA concentrations would also fall when insulin sensitivity is enhanced with weight loss in obese individuals. DESIGN/SETTING/PATIENTS/INTERVENTION: Twenty obese women classified as IR or insulin sensitive (IS) on the basis of their steady-state plasma glucose (SSPG) concentration during the insulin suppression test underwent 12 wk of dietary weight loss. OUTCOME MEASURES: Plasma glucose, insulin, and ADMA were measured at baseline and after weight loss; change in insulin resistance was quantified by repeating the SSPG after the dietary intervention. RESULTS: Although weight loss was similar in the two groups, significant improvements in SSPG, glucose, and insulin concentrations were confined to the IR group. Baseline plasma ADMA concentrations (mean +/- sd) were higher in IR subjects (1.69 +/- 0.44 vs. 1.18 +/- 0.45 micromol/liter, P = 0.02) and decreased to 1.20 +/- 0.22 micromol/liter (P < 0.001) with weight loss. In contrast, ADMA levels did not change with a similar extent of weight loss in the IS group. CONCLUSION: Plasma ADMA levels are higher in obese, IR women than in equally obese, IS women and decrease in response to weight loss when associated with enhancement of insulin sensitivity.
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McLaughlin et al. (2006) studied Obesity with or without insulin resistance (n=20). Dietary weight loss vs. Baseline / Insulin-sensitive group was evaluated on Plasma ADMA concentrations (p=<0.001). Dietary weight loss significantly decreased plasma ADMA concentrations in insulin-resistant obese women from 1.69 to 1.20 micromol/liter (P<0.001), but had no effect in insulin-sensitive obese women.
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