Key result
Discrete subaortic stenosis pathogenesis is increasingly attributed to a hemodynamic etiology where left ventricular outflow tract geometric derangements generate abnormal shear forces that trigger a fibrotic response.
Population
Patients with Discrete Subaortic Stenosis (DSS)
Design
Review
Authors
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Does not support practice changes in discrete subaortic stenosis; leaves open mechanistic pathways for future research.
This perspective paper outlines a research roadmap to investigate the hemodynamic and mechanobiological etiology of discrete subaortic stenosis to identify early targets for prevention.
Massé et al. (2018) conducted a review in Discrete subaortic stenosis. Discrete subaortic stenosis pathogenesis is increasingly attributed to a hemodynamic etiology where left ventricular outflow tract geometric derangements generate abnormal shear forces that trigger a fibrotic response.
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