Key result
In paediatric subvalvular aortic stenosis, 51% of natural history patients required surgery, with higher LVOT gradient and aortic regurgitation identified as independent predictors of worse outcome.
Why the study?
What are the natural history, surgical outcomes, and prognostic factors in paediatric patients with subvalvular aortic stenosis?
Population
24 studies pooling 2,285 paediatric patients with subvalvular aortic stenosis, comprising 809 natural…
Comparison
Surgical intervention for subvalvular aortic… vs Natural history (observational management)
Design
Meta-analysis
Authors
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Supports individualized surgical timing decisions in paediatric SAS; leaves open prospective validation of predictors.
Systematic Review (n=2,285)
What are the natural history, surgical outcomes, and prognostic factors in paediatric patients with subvalvular aortic stenosis?
In paediatric subvalvular aortic stenosis, higher LVOT gradient and aortic regurgitation are key predictors of worse outcomes, highlighting their importance in determining the optimal timing for surgical intervention.
Etnel et al. (2014) conducted a systematic review in Paediatric subvalvular aortic stenosis (n=2,285). Surgery vs. Natural history was evaluated on Prognosis / worse outcome. In paediatric subvalvular aortic stenosis, 51% of natural history patients required surgery, with higher LVOT gradient and aortic regurgitation identified as independent predictors of worse outcome.
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