Palladium-catalyzed hydrothiocarbonylation produces alkyl thioesters in styrenes, suggesting efficient synthesis.
A palladium-catalyzed nonacidic hydrothiocarbonylation of styrenes with CO and thiols has been developed. Utilizing a cyclopropane-based monophosphine ligand (TPhos), this protocol enables the efficient and branched-selective synthesis of alkyl thioesters under mild and neutral conditions with broad substrate scope and excellent functional group tolerance.
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Kuai et al. (2026) studied this question.
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