Mini-review illustrates the Vitamin Rheostat model linking vitamins to metabolic regulation, suggesting implications for nutrition.
Recent evidence implicates epigenetic mechanisms in vitamin metabolism, yet most studies remain focused on individual vitamins. In this mini-review, we extend beyond single-vitamin paradigms to propose the Vitamin Rheostat: a unifying model in which vitamins influence regulatory signaling networks that shape their own uptake, utilization, and degradation. By integrating fat-soluble vitamins (nuclear receptor-mediated signaling) and water-soluble vitamins (methyl-donor and enzymatic cofactor systems), this model provides a predictive and experimentally testable framework that may help explain inter-individual variability in response to vitamin intake. It repositions epigenetics as an active mediator in vitamin homeostasis and supports the development of chromatin-informed approaches to precision nutrition.
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Kubant et al. (2026) studied this question.
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