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The study aims to assess the clinical and bacteriological profiles and antibiotic susceptibility patterns in neonatal sepsis.

July 2, 2026CureusOpen Access

An Observational Study of Clinical Bacteriological Profile and Antibiotic Susceptibility Pattern of Neonatal Sepsis at a Tertiary Care Hospital

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The study aims to assess the clinical and bacteriological profiles and antibiotic susceptibility patterns in neonatal sepsis.
Conducted observational, cross-sectional study at NICU of MGM Medical College from September 2022 to June 2024.
Enrolled 200 neonates with clinical or culture-proven sepsis and performed blood cultures.
Antimicrobial susceptibility testing followed CLSI guidelines.
Culture positivity was found in 53 (26.5%) neonates; klebsiella pneumoniae was the most prevalent isolate in 12 (22.6%) cases.
Gram-negative organisms showed high resistance rates to third-generation cephalosporins.
Aminoglycosides and carbapenems demonstrated the best sensitivity among tested antibiotics.

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Observational study reports bacteriological profiles and antibiotic resistance in neonates, indicating urgent need for surveillance.

Aggarwal et al. (2026) studied this question.

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