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This study aims to evaluate the persistence of dysmorphic features associated with fetal alcohol spectrum disorders (FASD) into midlife.

Prenatal Alcohol Exposure and Dysmorphic Features in Adults at Midlife

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This study aims to evaluate the persistence of dysmorphic features associated with fetal alcohol spectrum disorders (FASD) into midlife.
Participants (n=192) were stratified by degree of dysmorphology observed earlier in life.
Standard dysmorphology examinations of 23 features were performed, blind to FASD/PAE status.
Hierarchical multiple and logistic regression analyses were conducted to assess the impact of experimental group and demographic variables on physical features.
Main effects were found for groups related to orbitofrontal circumference, palpebral fissure lengths, and philtrum scores.
Demographic factors moderated effects of experimental group for key features like philtrum length and vermilion border score.
Findings suggest FASD-related features persist into midlife, indicating ongoing diagnostic value.

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Randomized trial evaluates dysmorphic features related to fetal alcohol syndrome, indicating persistence into midlife.

Stoner et al. (2026) studied this question.

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