Pamidronate therapy in an adolescent patient chronic diffuse sclerosing osteomyelitis: Report of a case

Chronic diffuse sclerosing osteomyelitis is a rare, non-suppurative mandibular inflammatory disease with recurrent pain and swelling and no standardized treatment guidelines. This report described a 13-year-old girl with left mandibular chronic diffuse sclerosing osteomyelitis who achieved clinical and radiologic remission after a three-day intravenous pamidronate regimen (0.5 mg/kg on day 1 and 1.0 mg/kg on days 2–3, up to 30 mg/day) and favorable bone remodeling on follow-up imaging. These findings indicate that pamidronate may be an effective and safe therapeutic option for pediatric chronic diffuse sclerosing osteomyelitis, with bone turnover markers serving as useful adjunct indicators of treatment response.