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June 30, 2026Clinical PainOpen Access

Neurophysiology and Sensitization Mechanisms of Joint Pain

Yongbum Park Jun Hyeong Song

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Key Points

To explore the neurophysiological mechanisms underlying joint pain and their interactions at different levels.
Review of current knowledge on joint nociceptive mechanisms across peripheral, spinal, and supraspinal levels.
Joint pain involves complex interactions between peripheral sensitization and central nervous system factors.
Peripheral sensitization occurs through nociceptor activation and recruitment of silent nociceptors.
Spinal and supraspinal sensitization mechanisms contribute to the cognitive and emotional dimensions of pain.

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Implication

Review integrates nociceptive mechanisms in joint pain, highlighting implications for treatment strategies.

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Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6a4600209ed13430313104df https://doi.org/10.35827/cp.2026.25.1.20

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