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July 2, 2026PLoS ONEOpen Access

Impact of kidney function on the metabolome in the general population

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Authors

JLJohan LjunggrenMDMario Delgado-VelandíaJSJohan Sundström

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Overview

Randomized trial assesses metabolite associations with kidney function in the general population, suggesting links to cardiovascular risks.

Key Points

  • To evaluate the relationship between kidney function and metabolite levels in the general population.
  • Utilized three population-based cohorts (Epihealth, PIVUS, POEM) totaling 3,444 individuals.
  • Measured metabolites using mass spectroscopy and calculated eGFR via the CKD-EPI equation.
  • Applied multivariable linear regression to identify significant metabolite-eGFR correlations, adjusting for various health factors.
  • Identified 96 metabolites significantly associated with eGFR, mostly with negative correlations.
  • Top metabolites included creatinine, N-acetylalanine, and TMAP.
  • Pathway analysis revealed five enriched pathways related to amino acid metabolism.

Cite This Study

Ljunggren et al. (2026) studied this question.

synapsesocial.com/papers/6a4600489ed1343031310746https://doi.org/10.1371/journal.pone.0347652
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