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July 2, 2026International Journal of Retina and VitreousOpen Access

Evaluating the effectiveness of different topical anesthetic methods in reducing pain during intravitreal injections: a systematic review and meta-analysis

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Authors

RARenad Alhomidi AlmotiriZAZahraa Hussain AlsaggafYAYara Hamed Abosabaah

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Overview

Systematic review evaluates various anesthetic methods' pain reduction in adults undergoing intravitreal injections, suggesting improved patient comfort.

Key Points

  • This review aims to evaluate the efficacy and safety of various local anesthetic methods during intravitreal injections.
  • Systematic review and meta-analysis of randomized controlled trials following PRISMA guidelines.
  • Included studies focused on patients aged 18+ receiving local anesthesia for intravitreal injections with quantified pain scores.
  • Comprehensive search conducted on PubMed and Google Scholar for eligible English-language trials.
  • Analysis included 14 RCTs with 1,300 patients, showing no significant superiority of topical anesthetics (p=0.62).
  • Topical NSAIDs provided limited additional benefits, while physical cooling showed significant pain reduction.
  • Topical anesthetics were safer than subconjunctival injections, which had higher incidence of hemorrhage and chemosis.

Cite This Study

Almotiri et al. (2026) studied this question.

synapsesocial.com/papers/6a4600a29ed1343031310ac8https://doi.org/10.1186/s40942-026-00892-5
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