What question did this study set out to answer?

The research aims to understand how hemoglobin expression influences the conversion of guaiacol to muconic acid in Pseudomonas putida under well-oxygenated conditions.

July 2, 2026AMB ExpressOpen Access

Hemoglobin expression reduces aerobic bioconversion of guaiacol in Pseudomonas putida despite non-limiting oxygen

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Authors

FLFredrik LundLund University MDMatilda DellsonLund University NENélida Leiva ErikssonLund University

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Implication

Randomized trial evaluates hemoglobin's effect on guaiacol bioconversion in Pseudomonas putida, suggesting altered oxygen use impacts growth rates.

Key Points

The research aims to understand how hemoglobin expression influences the conversion of guaiacol to muconic acid in Pseudomonas putida under well-oxygenated conditions.
Two plant hemoglobin genes from Arabidopsis thaliana and Beta vulgaris were expressed in Pseudomonas putida.
Growth on glucose and vanillin was evaluated alongside whole-cell bioconversion of guaiacol.
Strains were assessed under controlled bioreactor conditions.
Expression of hemoglobin improved glucose growth but not on vanillin.
AHb2 co-expression with gcoAB led to reduced growth and respiration rates under non-limiting oxygen.
Conversion rates of guaiacol to cis, cis-muconic acid decreased, but product yield remained unaffected.

Cite This Study

Lund et al. (2026) studied this question.

synapsesocial.com/papers/6a4600a29ed1343031310b30 https://doi.org/10.1186/s13568-026-02089-3

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Implication

Randomized trial evaluates hemoglobin's effect on guaiacol bioconversion in Pseudomonas putida, suggesting altered oxygen use impacts growth rates.

Hemoglobin expression reduces aerobic bioconversion of guaiacol in Pseudomonas putida despite non-limiting oxygen

Discussion

Member takes

Implication

Key Points

Cite This Study

Hemoglobin expression reduces aerobic bioconversion of guaiacol in Pseudomonas putida despite non-limiting oxygen

Discussion

Member takes

Implication

Key Points

Cite This Study

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