The Impact of Periodontal Therapy on Disease Activity in Patients with Rheumatoid Arthritis and Concomitant Periodontitis: A Systematic Review and Meta-Analysis
Systematic review reports periodontal therapy reduces disease activity in rheumatoid arthritis and periodontitis patients, suggesting potential therapeutic benefits.
Key Points
This review aims to assess the impact of periodontal therapy on disease activity for patients with rheumatoid arthritis and periodontitis.
Conducted a systematic review and meta-analysis of randomized controlled trials (RCTs)
Assessed risk of bias using RoB-2
Analyzed Disease Activity Score based on C-reactive protein (DAS28-CRP) and erythrocyte sedimentation rate (DAS28-ESR) in separate random-effects models.
At 3 months, DAS28-CRP significantly decreased with a mean difference of -0.84 (95% CI -1.38 to -0.29)
DAS28-ESR also showed a significant change-from-baseline estimate of -1.27 (95% CI -2.22 to -0.31) at 3 months
Notably, substantial heterogeneity was observed in DAS28-ESR estimates.