Rapid and Selective Fluorescent Sensing of Histidine Driven by Metal-Specific Displacement in AIE-Based Complexes

Q: What does this research mean for the field?

Modulating metal-dependent dissociation energetics in AIE-based complexes enables highly selective and rapid fluorescent sensing of histidine with a detection limit of 4.66 nM, providing a new coordination chemistry strategy for probe design. Novelty: ClaimNovelty.METHODOLOGICAL. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

Zhizhong Zhao; Lijuan Liang; Xin Wang; Xi Zhang; Can Diao; Xiangyuan Yan; Pingru Su; Yu Tang

doi:10.1021/acs.inorgchem.6c02450

June 30, 2026Inorganic Chemistry

Rapid and Selective Fluorescent Sensing of Histidine Driven by Metal-Specific Displacement in AIE-Based Complexes

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Key Points

This study aims to develop a highly selective fluorescent probe for histidine that can effectively distinguish it from other amino acids.
Developed a fluorescent probe using AIE-based complexes and coordination chemistry strategies.
Tested selectivity against 20 other amino acids and determined sensitivity with a detection limit of 4.66 nM.
The probe showed a detection limit of 4.66 nM for histidine.
Successfully discriminated histidine from 20 other amino acids, indicating high selectivity.
Used metal-specific displacement to modulate dissociation energetics.

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Implication

Demonstrates a new fluorescent probe for histidine detection, suggesting advances in chemical sensing.

Abstract

serves as a highly selective and rapid fluorescent probe for His, discriminating against 20 other amino acids with a detection limit of 4.66 nM. This work establishes a coordination chemistry strategy for designing small-molecule probes by modulating metal-dependent dissociation energetics in AIE complexes, moving beyond conventional PET mechanisms.

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Cite This Study

Zhao et al. (2026) studied this question.

synapsesocial.com/papers/6a46015f9ed13430313112e0 https://doi.org/10.1021/acs.inorgchem.6c02450

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Rapid and Selective Fluorescent Sensing of Histidine Driven by Metal-Specific Displacement in AIE-Based Complexes

Key Points

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Implication

Abstract

Discussion

Cite This Study

Rapid and Selective Fluorescent Sensing of Histidine Driven by Metal-Specific Displacement in AIE-Based Complexes

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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