Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program

Q: What does this research mean for the field?

Women with endometriosis and adenomyosis exhibit distinct symptom phenotypes, including a unique psychological/neurological cluster and a high pain-gastrointestinal cluster, which are associated with poorer quality of life and challenge traditional diagnostic frameworks. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

Oksana Goroshchuk; Noelia Pérez-Gómez; Francisco Carmona; Hugh S. Taylor; Idhaliz Flores; Miriam Saiz‐Rodríguez; Dóra Koller

doi:10.1093/humrep/deag101

June 10, 2026Human Reproduction

Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program

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Key Points

The aim is to identify distinct symptom clusters in women with endometriosis and adenomyosis and their impact on quality of life.
Large-scale cross-sectional cohort study of 22,438 women from the All of Us Research Program
Conducted four latent class analyses on symptom data including 19 self-reported and EHR-derived symptoms
Used multinomial logistic regression to assess predictors of class membership and relation to quality of life outcomes.
Identified four symptom phenotypes including high pain-gastrointestinal and psychological-neurological clusters.
High class associated with lower health scores and reduced social satisfaction.
Adenomyosis patients showed no asymptomatic group, indicating higher disease burden.

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Implication

Characterizes symptom clusters affecting quality of life in women with endometriosis and adenomyosis, suggesting a need for personalized management.

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Cite This Study

Goroshchuk et al. (2026) studied this question.

synapsesocial.com/papers/6a46cbf11de2a4889543154a https://doi.org/10.1093/humrep/deag101

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Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Characterizing endometriosis and adenomyosis symptom clusters and their impact on quality of life in the All of Us Research Program

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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