Key result
CHA2DS2-VASc score >6 linked to ~41-fold higher 90-day readmission risk versus score 0.
Why the study?
To evaluate the CHA2DS2-VASc score for predicting hospital readmission risk and length of stay in patients admitted with primary AF.
Does the CHA2DS2-VASc score predict 90-day hospital readmission and length of stay in patients admitted with primary atrial fibrillation?
Cohort (n=717)
No
Does the CHA2DS2-VASc score predict 90-day hospital readmission and length of stay in patients admitted with primary atrial fibrillation?
Hazard Ratio: 41 (95% CI 31–72)
The CHA2DS2-VASc score, traditionally used for stroke risk stratification, is also a strong predictor of length of stay and 90-day readmission in patients hospitalized for primary atrial fibrillation.
May inform AF readmission risk assessment; extends CHA2DS2-VASc utility but leaves clinical adoption open.
Objectives We assessed the CHA 2 DS 2 -VASc score for predicting hospital readmission risk and length of stay (LOS) in patients admitted with primary atrial fibrillation (AF). Methods This retrospective cohort study included patients with index admission for AF to Latakia’s tertiary center (May 2021–November 2023). Patients were followed 90 days to assess readmission. CHA 2 DS 2 -VASc was correlated with 90-day readmission, inpatient all-cause mortality, and LOS during index admission. Results In total, 717 patients were included; 320 (45%) were readmitted to the hospital within 90 days (58% men, 65% aged <65 years). Inpatient mortality was 4%; the median LOS was 2 days. There was an increase in the incident rate ratio (IRR) of LOS starting from a CHA 2 DS 2 -VASc of 2 (IRR: 2, 95% confidence interval [CI]: 1.7–2.2) to a score of >6 (IRR: 5, 95% CI: 1.8–10.7), compared with a score of 0. There was an incremental increase in the hazard ratio (HR) of readmission from a score of 1 (HR: 2.3, 95% CI: 1.3–4.1) to a score of >6 (HR: 41, 95% CI: 31–72) compared with a CHA 2 DS 2 -VASc of 0. Conclusion CHA 2 DS 2 -VASc could predict 90-day hospital readmission and LOS during the index admission in patients admitted with primary AF.
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Antoun et al. (2025) conducted a cohort in primary atrial fibrillation (n=717). CHA2DS2-VASc score >6 vs. CHA2DS2-VASc score of 0 was evaluated on 90-day hospital readmission (HR 41, 95% CI 31-72). A CHA2DS2-VASc score >6 was associated with a significantly higher risk of 90-day hospital readmission compared to a score of 0 (HR 41; 95% CI 31-72).
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