Key result
Rivaroxaban demonstrated superior efficacy to enoxaparin for VTE prophylaxis after total hip and knee arthroplasty, but data suggest an increased risk of bleeding.
Why the study?
Does rivaroxaban improve VTE prophylaxis and what is its safety profile compared to enoxaparin in patients undergoing total hip and total knee arthroplasty?
Population
Patients undergoing total hip and total knee arthroplasty
Comparison
Rivaroxaban vs Enoxaparin
Design
Review
Authors
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Rivaroxaban may reduce post-arthroplasty VTE versus enoxaparin but raises bleeding; leaves open optimal prophylaxis choice pending randomized data.
Does rivaroxaban improve VTE prophylaxis and what is its safety profile compared to enoxaparin in patients undergoing total hip and total knee arthroplasty?
Rivaroxaban offers superior efficacy for VTE prophylaxis post-arthroplasty compared to enoxaparin, though it carries a higher bleeding risk.
Russell et al. (2013) conducted a review in Venous thromboembolism after total hip and total knee arthroplasty. Rivaroxaban vs. Enoxaparin was evaluated. Rivaroxaban demonstrated superior efficacy to enoxaparin for VTE prophylaxis after total hip and knee arthroplasty, but data suggest an increased risk of bleeding.
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