Key result
Artificial gravity training did not differ from control during 60-day bed rest; pooled analysis showed bed rest increased resting heart rate (P<0.0001) and decreased cardiac output (P=0.0096).
Why the study?
Reduced physical activity increases heart failure risk, but non-invasive methodologies detecting subclinical myocardial functional changes are not available.
Does artificial gravity through centrifugation prevent subclinical changes in myocardial function during 60-day head-down-tilt bed rest in healthy persons?
Population
24 healthy persons (eight women)
Comparison
Control vs continuous vs intermittent artificial gravity training
Design
Three-group randomized study with pooled analysis
Follow-up
60 day
Authors
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Artificial gravity training does not mitigate bed rest-induced hemodynamic changes; leaves open its utility in clinical deconditioning.
RCT (n=24)
Does artificial gravity through centrifugation prevent subclinical changes in myocardial function during 60-day head-down-tilt bed rest in healthy persons?
Prolonged head-down-tilt bed rest induces functional changes in cardiac strain and hemodynamics without structural remodeling, suggesting strain measurements have limited utility for assessing physical deconditioning.
Hoffmann et al. (2020) conducted an RCT in Healthy persons (physical deconditioning) (n=24). Artificial gravity training on a short-arm centrifuge vs. Control group (no centrifugation) was evaluated on Cardiac morphology, function, strain, and haemodynamics. Artificial gravity training did not differ from control during 60-day bed rest; pooled analysis showed bed rest increased resting heart rate (P<0.0001) and decreased cardiac output (P=0.0096).
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