Key result
The minor C allele of the GJA1 gene polymorphism (rs1015451) was significantly associated with a higher 24-hour total heart rate during atrial fibrillation (P=3.7×10^-6).
Why the study?
Heart rate during atrial fibrillation varies considerably among individuals, but determinants beyond AV nodal conduction and the autonomic nervous system remain unclear.
Is the minor C allele of the GJA1 gene polymorphism (rs1015451) associated with higher heart rate during atrial fibrillation in patients with persistent AF?
Observational (n=457)
No
Is the minor C allele of the GJA1 gene polymorphism (rs1015451) associated with higher heart rate during atrial fibrillation in patients with persistent AF?
Absolute Event Rate: 124573% vs 111454%
p-value: p=3.7×10^-6
The minor C allele of the GJA1 gene polymorphism (rs1015451) is associated with higher heart rates and faster intra-atrial conduction during AF, potentially serving as a novel genetic marker for refractory tachycardic AF.
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Okamura et al. (2022) conducted an observational in Persistent atrial fibrillation (n=457). GJA1 gene polymorphism (rs1015451) minor C allele vs. Major T allele (TT genotype) was evaluated on 24-hour total heart rate (THR) (p=3.7×10^-6). The minor C allele of the GJA1 gene polymorphism (rs1015451) was significantly associated with a higher 24-hour total heart rate during atrial fibrillation (P=3.7×10^-6).
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