Key result
Pericardial fluid Xpert MTB/RIF enables rapid diagnosis and successful guided treatment of tuberculous pericarditis.
Why the study?
Tuberculosis remains the leading cause of pericardial effusion in endemic developing countries and must not be dismissed.
Case Report (n=1)
No
Highlights the utility of rapid molecular testing for diagnosing tuberculous pericarditis in endemic regions and the benefit of combined antitubercular and corticosteroid therapy to prevent complications.
May expedite tuberculous pericarditis diagnosis via Xpert MTB/RIF on pericardial fluid; leaves open validation in prospective cohorts.
Tuberculosis is a transmissible disease caused by the bacterium Mycobacterium tuberculosis . It is the leading cause of mortality due to infectious diseases. Tuberculous pericarditis is one of the manifestations of extrapulmonary tuberculosis and represents the primary cause of pericardial effusion in developing countries. We present the case of a 71-year-old male patient with a history of 1 month of dyspnea, accompanied by paroxysmal nocturnal dyspnea and unintentional weight loss. An echocardiogram revealed the presence of severe pericardial effusion, for which pericardiocentesis was performed, and the pericardial fluid was analyzed using the Xpert MTB/RIF test, which confirmed the presence of Mycobacterium tuberculosis without resistance to Rifampicin. This is a case of Tuberculous Pericarditis as the cause of pericardial effusion, in which the etiological diagnosis was made possible through molecular biological analysis of the pericardial fluid. The importance of disseminating such cases lies in emphasizing that, even in the 21st century, in developing countries like Honduras, it is crucial not to dismiss tuberculosis infection, as it remains the leading cause of pericardial effusion in endemic regions. • Pericardial tuberculosis is the leading cause of pericardial effusion in developing countries. • Corticosteroid treatment is especially indicated in HIV-negative patients to prevent constrictive pericarditis. • Cardiac tamponade may occur as the main complication of pericardial effusion.
No takes yet. Share an insight, caveat, or question.
Irias et al. (2024) conducted a case report in Tuberculous pericarditis (n=1). Pericardiocentesis, anti-tuberculosis therapy, and corticosteroids was evaluated on Clinical resolution. The Xpert MTB/RIF test enabled rapid etiological diagnosis of tuberculous pericarditis from pericardial fluid, leading to successful treatment with pericardiocentesis, anti-tuberculosis therapy, and corticosteroids.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: