Key result
Intracerebral and intrafoetal inoculation of porcine enteroviruses caused encephalomyelitis and foetal death respectively, whereas oral infection induced no adverse effects.
Porcine enteroviruses isolated in Victoria can cause encephalomyelitis and reproductive failure when inoculated intracerebrally or intrafoetally, but not orally.
Answers are grounded in this paper and cite their sources.
Supports route-dependent pathogenicity in experimental pig models; leaves open relevance to natural transmission and field control.
Approximately 23 viruses were isolated from healthy pigs, pigs with encephalitis, and in cases of reproductive failure. Five viruses were identified as enteroviruses and a total of 10 isolates were shown to cross-react serologically to varying degrees. Twenty viruses were neutralised by a reference antiserum of serotype 8 porcine enterovirus. Intracerebral inoculaton of colostrum-deprived piglets with 2 of the characterised viruses caused lesions of encephalomyelitis which were not induced by oral infection. Intrafoetal inoculation of 2 sows with one characterised faecal isolate caused foetal death and abortion, but no adverse effects followed oral dosage.
No takes yet. Share an insight, caveat, or question.
Forman et al. (1982) studied Porcine enterovirus infection. Intracerebral or intrafoetal inoculation of porcine enteroviruses vs. Oral infection was evaluated on Lesions of encephalomyelitis, foetal death and abortion. Intracerebral and intrafoetal inoculation of porcine enteroviruses caused encephalomyelitis and foetal death respectively, whereas oral infection induced no adverse effects.
Synapse has enriched 10 related papers. Consider them for comparative context: