Key result
Physical training initiated after the onset of doxorubicin-induced cardiotoxicity significantly improved left ventricular ejection fraction (77.0% vs 62.0%) and exercise tolerance in rats.
Why the study?
Doxorubicin chemotherapy is associated with cardiotoxicity and heart failure, while physical exercise produces favorable morphofunctional adaptations and may reverse cardiac dysfunction.
Does physical training improve myocardial structure, cardiac function, and exercise tolerance in rats with doxorubicin-induced cardiomyopathy?
Does physical training improve myocardial structure, cardiac function, and exercise tolerance in rats with doxorubicin-induced cardiomyopathy?
Absolute Event Rate: 77% vs 62%
p-value: p=<0.05
Physical training improves cardiac structure and function in a rat model of doxorubicin-induced cardiomyopathy.
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Souza et al. (2022) studied Doxorubicin-induced cardiomyopathy (n=30). Physical training (swimming) vs. Sedentary (no physical training) was evaluated on Left ventricular ejection fraction (LVEF) (p=<0.05). Physical training initiated after the onset of doxorubicin-induced cardiotoxicity significantly improved left ventricular ejection fraction (77.0% vs 62.0%) and exercise tolerance in rats.
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