Key result
Mitogen-activated protein kinases (MAPKs) play complex, sometimes contradictory roles in cardiac development, hypertrophy, ischemia/reperfusion injury, and pathological remodeling.
Design
Review
Authors
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MAPK dual roles complicate therapeutic targeting in cardiac disease; leaves open context-specific mechanisms for resolution in future studies.
MAPK signaling pathways exhibit complex, dual roles in cardiac pathogenesis, complicating their evaluation as viable therapeutic targets.
Rose et al. (2010) conducted a review in Cardiac development and pathogenesis. Mitogen-activated protein kinases (MAPKs) was evaluated. Mitogen-activated protein kinases (MAPKs) play complex, sometimes contradictory roles in cardiac development, hypertrophy, ischemia/reperfusion injury, and pathological remodeling.
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