Key result
Chemotherapy in breast cancer patients significantly reduced left atrial mechanical function, including reservoir strain (from 30.9% to 28.6%), and increased left atrial mechanical dispersion.
Why the study?
Left atrial function and mechanical dispersion changes in breast cancer patients treated with chemotherapy remain unclear.
Does chemotherapy impair left atrial function and mechanical dispersion in breast cancer patients?
Cohort (n=121)
No
Does chemotherapy impair left atrial function and mechanical dispersion in breast cancer patients?
Absolute Event Rate: 28.6% vs 30.9%
p-value: p=<0.05
Chemotherapy in breast cancer patients is associated with a significant decline in left atrial mechanical function and an increase in mechanical dispersion as assessed by speckle-tracking echocardiography.
LA dysfunction after chemotherapy may support surveillance in breast cancer; leaves open outcome prediction and intervention trials.
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Chen et al. (2022) conducted a cohort in Breast cancer (n=121). Chemotherapy vs. Baseline (pre-chemotherapy) and healthy controls was evaluated on Left atrial strain during reservoir phase (LASr) at 12 months (p=<0.05). Chemotherapy in breast cancer patients significantly reduced left atrial mechanical function, including reservoir strain (from 30.9% to 28.6%), and increased left atrial mechanical dispersion.
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