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June 30, 2026Gut and LiverOpen Access

Sex and Gender Differences in Peptic Ulcer Disease: A Scoping Review with Exploratory Quantitative Synthesis for Clinical Guideline Development

Chang Seok Bang Seung Joo Kang Jieun Jang Yonghoon Choi Seung Young Kim Chung Hyun Tae Hyeong Ho Jo Nayoung Kim Byung‐Wook Kim

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Key Points

This review aims to explore sex and gender differences in peptic ulcer disease to guide clinical recommendations.
Conducted a scoping review following PRISMA-ScR guidelines.
Searched multiple databases for studies on epidemiology, hormonal factors, treatment responses, and outcomes until October 2025.
Reviewed and extracted data from 68 studies meeting inclusion criteria.
Elderly females show a heightened risk of bleeding and mortality, especially when using NSAIDs or aspirin.
Postmenopausal status correlated with higher peptic ulcer disease risk and complications, including perforation and mortality.
Females experienced more adverse events during H. pylori treatment, despite similar eradication rates and higher recurrence rates.

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Implication

Scoping review maps sex and gender differences in peptic ulcer disease, suggesting implications for guidelines.

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Cite This Study

Bang et al. (2026) studied this question.

synapsesocial.com/papers/6a4750f45c29257aa2578753 https://doi.org/10.5009/gnl260054

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3Sex and Gender Differences in Patients with Gastric Cancer: A Systematic ReviewSystematic Review · 2026 · 1 citations
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