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This study aims to evaluate the protective effects of a 20% marigold extract oil containing lutein and zeaxanthin against retinal injury.

July 3, 2026In VivoOpen Access

Antioxidant and Neuroprotective Effects of 20% Marigold Extract Oil (Lutein/Zeaxanthin Complex) in LED-induced Retinal Injury and A2E-mediated ARPE-19 Models

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Randomized trial investigates L/Z complex's effects on retinal injury, indicating potential for retinal degeneration treatment.

This study aims to evaluate the protective effects of a 20% marigold extract oil containing lutein and zeaxanthin against retinal injury.
In vitro testing on ARPE-19 cells loaded with A2E exposed to blue light (6,000 lux) for 20 minutes.
In vivo testing on rats exposed to 750 lux LED for 48 hours after 4-week oral L/Z complex administration.
Assessment of cell viability, inflammatory cytokines, antioxidant enzymes, and retinal histopathology.
ARPE-19 cell viability reduced to 28.15±3.67% due to A2E-mediated blue light, with increased inflammatory cytokines.
L/Z complex significantly reduced NF-κB and pro-inflammatory cytokines while enhancing HO-1 and antioxidant enzymes.
In rats, L/Z complex preserved ONL thickness, reduced pro-inflammatory cytokines, and increased total antioxidant capacity.

Kim et al. (2026) studied this question.

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